Gain-of-Function Mutational Activation of Human tRNA Synthetase Procytokine
نویسندگان
چکیده
منابع مشابه
Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex
Human cytosolic aspartyl-tRNA synthetase (DRS) catalyzes the attachment of the amino acid aspartic acid to its cognate tRNA and it is a component of the multi-tRNA synthetase complex (MSC) which has been known to be involved in unexpected signaling pathways. Here, we report the crystal structure of DRS at a resolution of 2.25 Å. DRS is a homodimer with a dimer interface of 3750.5 Å(2) which com...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2007
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2007.10.016